Intravenous Immunoglobulin Market: Plasma Fractionation and Antibody Therapy

The global intravenous immunoglobulin market size was valued at USD 14.19 billion in 2024 and is expected to hit around USD 28.71 billion by 2034 with a CAGR of 7.3% from 2025 to 2034.

Intravenous Immunoglobulin Market Key Takeaways:

• The North America dominated the Intravenous Immunoglobulin (IVIG) market, with a global share of 46.31% in 2024.
• The IVIG market in the U.S. continues to dominate the North American market, holding a share of 80.39% in 2024.
• The IVIG market in Asia Pacific is expanding rapidly, driven by a significant increase in the incidence of immunodeficiency diseases, particularly in countries such as China, India, Japan, and Australia.
• The immunodeficiency diseases segment accounted for the largest revenue share of 19.98% in 2024. 
• The Kawasaki disease segment is expected to exhibit the fastest growth in the market over the forecast period.
• The hospital pharmacies segment held the largest revenue share of 57.43% in 2024.
• The Specialty pharmacy is expected to grow considerably over the forecast period. 

Intravenous Immunoglobulin Market Report Scope

The intravenous immunoglobulin market refers to the production, distribution, and application of intravenous immunoglobulin which is a do,se of donated immune system antibodies. Provider will infuse intravenous immunoglobulin (IVIG) through a vein in our arm. We may need IVIG if a health condition or treatment weakens the natural immune system. It is safe, effective, and low-risk. Intravenous immunoglobulin contains the pooled immunoglobulin G (IgG) immunoglobulins from the plasma of approximately a thousand or more blood donors. Intravenous immunoglobulin is a product made up of human antibodies from blood donors that can be given intravenously. It may be referred to as a plasma derivative due to it is made from blood plasma.

There is a large body of evidence that intravenous immunoglobulin (IVIG) can modulate an immune reaction at the level of T-cells, B-cells, and macrophages, interfere with antibody production and degradation, modulate the complement cascade, and have effects on the cytokine network. In immunology, intravenous immunoglobulin is used in the treatment of primary antibody deficiency (PAD) in ophthalmology, rheumatology, and nephrology. It has been used to treat vasculitis systematic lupus erythematosus (SLE), mucous membrane pemphigoid, and uveitis, and in dermatology, it is used mostly to treat Kawasaki Syndrome. IVIG's success rate can range from 60% to 80%, depending on the condition being treated, individual response, and the specific IVIG brand.

Increasing investment in immunoglobulins research and development (R&D) is driving the growth of the intravenous immunoglobulin market. R&D offers productivity and product differentiation. Firms gain a competitive benefit by performing in some way that their rivals cannot easily replicate. R&D efforts lead to an enhanced type of business process, cutting marginal costs, and increasing marginal productivity, and it is easier to outpace competitors. R&D can lead to innovations in business. These may be in terms of new products and services, enhanced processes, and new ways to interact with your customers. These innovations can result in greater profits and lower costs. Innovation is also a useful way to grow business. R&D allows companies to create products that are difficult for their competitor to replicate. R&D efforts can lead to enhanced productivity that helps increase margins, further creating an edge in outpacing competitors.

Increasing advances in plasma collection, fractionation, and purification technologies drive the growth of the intravenous immunoglobulin market. Modern plasma product production technology remains largely based on the ethanol fractionation process, but much has evolved in the last few years to enhance product purity, enhance recovery of immunoglobulin G, and isolate new plasma proteins like α1-protease inhibitor, von Willebrand factor, and protein. Plasma protein fraction is a plasma protein solution used to treat coagulation factor deficiencies, reverse anticoagulation effects, and shock from a loss of plasma fluids, and is used in plasma exchange procedures. Proteins have many roles in our body. It helps repair and build our body’s tissues, allows metabolic reactions to take place, and coordinates bodily functions. Additionally, providing our body with a structural framework, proteins also maintain proper pH and fluid balance. Fractionation reduces the complexity of a protein sample by separating proteins into different classes based on the biophysical properties of the proteins, like solubility, cellular location, charge, and size. It is a clean and eco-friendly technique that minimizes waste and is unlike wet chemical processes.

According to Volza’s Global Import data, the world imported 23 shipments of intravenous immunoglobulin from December 2022 to November 2023. These imports were supplied by 10 exporters to 11 Global buyers, marking a growth rate of -23% compared to the preceding twelve months.